"AsedaSciences has developed a much needed platform that will provide medicinal chemists with actionable biologically relevant knowledge during all stages of lead optimization - the user interface is clear and has flexible functionality that will help chemists review, analyze and select compounds for progression in a very timely and straightforward manner. I predict that this will become an indispensable tool on a chemist's desktop. The user interface looks great and I would use this tool in a heartbeat"
“AsedaSciences goes beyond a toxicity screen—they have developed a reproducible, high-content cellular screening system that allows for an evaluation of cellular and metabolic stress. Simple ‘live/dead’ cellular health assays have limited utility because the result is binary. By examining cell metabolic/physiologic responses to xenobiotics with the AsedaSciences approach, one can start to tease out secondary/unintended targets and also understand whether these effects might be adverse or actually beneficial. This is an information-rich system that chemists will want to use to try and understand how a compound perturbs various cellular processes.”
“This innovative technology can quickly assess a compound's inherent ability to cause acute cellular stress, which often leads to toxicity. Based on multiple retrospective analyses on hundreds of preclinical compounds and marketed drugs, along with discontinued and boxed warning drugs, the AsedaSciences methodology accurately predicted agents with higher toxicity risks. Thus, the predictions provide drug hunters with data to allow prioritization of the most promising compounds for progression into higher investment pharmacology and safety studies. The results also shows alignment with some human-specific safety risks, which may not manifest prior to human exposures. Given the capability of fast turnaround times, iterative SAR work to improve the safety profile of potential drug candidates seems a particularly impactful application in hit to lead and lead optimization campaigns. This important new tool will no doubt lead to significant time savings and productivity enhancements in drug discovery.”